cellular_adaptation cell_injury reversible_injury irreversible_injury atrophy hypertrophy hyperplasia metaplasia dysplasia neoplasia cell_death apoptosis necrosis necroptosis pyroptosis autophagy senescence oxidative_stress mitochondrial_dysfunction membrane_damage dna_damage protein_misfolding er_stress lysosomal_dysfunction dystrophic_calcification metastatic_calcification steatosis hydropic_change genomic_instability cell_cycle_arrest