Summary

myasthenia_gravis is an autoimmune disorder of the neuromuscular_junction causing skeletal_muscle_weakness with fatigability. Most cases have autoantibodies to acetylcholine_receptors; a subset targets MuSK. Common early signs are ptosis and diplopia. bulbar_symptoms include dysphagia and dysarthria. respiratory_muscles may be affected, risking myasthenic_crisis. Symptoms fluctuate, worse with activity, better with rest. thymus_abnormalities are frequent. Sensation and reflexes are usually normal. ocular_symptoms are common at onset, and the course is chronic but variable.