Summary

huntington_disease is an inherited neurodegenerative disorder. It is autosomal_dominant, caused by a CAG_repeat_expansion in the HTT_gene on chromosome_4. Usual adult_onset with a progressive_course. Hallmark features are chorea, cognitive_decline, and psychiatric_symptoms. genetic_testing detects the mutation; anticipation can lead to earlier, more severe disease. Neurodegeneration affects the basal_ganglia. There is no_cure; care centers on symptom management and family support. A positive family_history is common.